{"id":7794983993515,"title":"PEA (Palmitoylethanolamide) 400 mg","handle":"pea-palmitoylethanolamide-400-mg","description":"\u003cul\u003e\n\n\u003cli\u003eFor chronic pain relief\u003c\/li\u003e\n\n\u003cli\u003e Offers a natural source of PEA from non-GMO saffron oil\u003c\/li\u003e\n\n\u003cli\u003e Micronized for better bioavailability\u003c\/li\u003e\n\n\u003cli\u003e Provides 400 mg of PEA in each capsule, allowing for easy, clinically relevant dosing\u003c\/li\u003e\n\n\u003cli\u003e Suitable for vegetarians and vegans\u003c\/li\u003e\n\n\n\u003c\/ul\u003e\n [TABS]\n\u003ch5\u003e Description\u003cbr\u003e\n\n\u003c\/h5\u003e\n\u003cp\u003e Palmitoylethanolamide (PEA) is an endogenously produced lipid that mediates the resolution of neuroinflammation and clinically reduces pain of various origins. PEA is a type of ethanolamine fatty acid produced in microglia and mast cells, where it reduces the activation of these two cell types; PEA levels are increased in brain areas involved in nociception and appear to modulate protective responses to both inflammation and pain. Its effects are mediated by direct activation of PPAR-a and GPR55 receptors, and potentially by indirect activation of CB1 and CB2 receptors and the TRPV1 channel (i.e. the capsaicin receptor).\u003cbr\u003e\u003cbr\u003e In clinical trials, PEA has been shown to be effective in reducing pain levels related to various chronic conditions (lasting at least 6 months) when pain was not controlled by standard therapies, by demonstrating its effectiveness both alone and in combination with standard treatments. PEA has been shown to be effective for pain resulting from nerve compression syndromes, including sciatica and carpal tunnel syndrome. Randomized trials have also shown benefit for pain control in specific conditions, including TMJ, as well as for depressive symptoms in major depressive disorder when used in conjunction with antidepressants. Furthermore, PEA has been shown to improve endothelial function and reduce intraocular pressure in patients with ocular hypertension.\u003c\/p\u003e\n\u003ch5\u003e Dosage\u003cbr\u003e\n\n\u003c\/h5\u003e\n\u003cp\u003e\u003cmeta charset=\"UTF-8\"\u003e \u003cb data-mce-fragment=\"1\"\u003eAdults:\u003c\/b\u003e \u003cspan data-mce-fragment=\"1\"\u003e1 capsule 1 to 3 times daily or as recommended by a healthcare practitioner.\u003c\/span\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003e Nutritional information\u003cbr\u003e\n\n\u003c\/h5\u003e\n\u003cp\u003e \u003cb\u003eMedicinal ingredients per capsule:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul\u003e\n\n\u003cli\u003e Palmitoylethanolamide (PEA) 400 mg\u003cbr\u003e PEA (palmitoylethanolamide) is a fatty acid-like compound extracted from non-GMO safflower oil. Micronized for better solubility and absorption.\u003c\/li\u003e\n\n\n\u003c\/ul\u003e\n\u003cp\u003e\u003cmeta charset=\"UTF-8\"\u003e \u003cspan\u003e\u003cb\u003eNonmedicinal ingredients:\u003c\/b\u003e Vegetable capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), silica, stearic acid.\u003c\/span\u003e\u003c\/p\u003e","published_at":"2023-11-10T12:37:33-05:00","created_at":"2023-11-10T12:37:34-05:00","vendor":"Bioclinic Naturals","type":"","tags":["Capsules","Douleur \/ Inflammation","Mélange \/ Synergie","Sans gluten","Sans OGM","Sans produits laitiers","SYSTÈME OSTÉO-MUSCULAIRE \u0026 TÉGUMENTAIRE","Végane"],"price":4499,"price_min":4499,"price_max":4499,"available":true,"price_varies":false,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":43152806183083,"title":"90 Capsules","option1":"90 Capsules","option2":null,"option3":null,"sku":"pea-bioclinic-naturals-90c","requires_shipping":true,"taxable":true,"featured_image":{"id":34993526014123,"product_id":7794983993515,"position":1,"created_at":"2023-11-10T12:37:34-05:00","updated_at":"2025-02-17T13:23:22-05:00","alt":null,"width":316,"height":600,"src":"\/\/www.unytii.com\/cdn\/shop\/products\/oqnttfro76zilsrlrqef.jpg?v=1739816602","variant_ids":[43152806183083]},"available":true,"name":"PEA (Palmitoylethanolamide) 400 mg - 90 Capsules","public_title":"90 Capsules","options":["90 Capsules"],"price":4499,"weight":0,"compare_at_price":null,"inventory_management":"shopify","barcode":"629022093311","featured_media":{"alt":null,"id":27439638708395,"position":1,"preview_image":{"aspect_ratio":0.527,"height":600,"width":316,"src":"\/\/www.unytii.com\/cdn\/shop\/products\/oqnttfro76zilsrlrqef.jpg?v=1739816602"}},"requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/www.unytii.com\/cdn\/shop\/products\/oqnttfro76zilsrlrqef.jpg?v=1739816602","\/\/www.unytii.com\/cdn\/shop\/files\/pea-bioclinic-naturals-90c.png?v=1739816602"],"featured_image":"\/\/www.unytii.com\/cdn\/shop\/products\/oqnttfro76zilsrlrqef.jpg?v=1739816602","options":["Size"],"media":[{"alt":null,"id":27439638708395,"position":1,"preview_image":{"aspect_ratio":0.527,"height":600,"width":316,"src":"\/\/www.unytii.com\/cdn\/shop\/products\/oqnttfro76zilsrlrqef.jpg?v=1739816602"},"aspect_ratio":0.527,"height":600,"media_type":"image","src":"\/\/www.unytii.com\/cdn\/shop\/products\/oqnttfro76zilsrlrqef.jpg?v=1739816602","width":316},{"alt":null,"id":27496970879147,"position":2,"preview_image":{"aspect_ratio":1.795,"height":414,"width":743,"src":"\/\/www.unytii.com\/cdn\/shop\/files\/pea-bioclinic-naturals-90c.png?v=1739816602"},"aspect_ratio":1.795,"height":414,"media_type":"image","src":"\/\/www.unytii.com\/cdn\/shop\/files\/pea-bioclinic-naturals-90c.png?v=1739816602","width":743}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003cul\u003e\n\n\u003cli\u003eFor chronic pain relief\u003c\/li\u003e\n\n\u003cli\u003e Offers a natural source of PEA from non-GMO saffron oil\u003c\/li\u003e\n\n\u003cli\u003e Micronized for better bioavailability\u003c\/li\u003e\n\n\u003cli\u003e Provides 400 mg of PEA in each capsule, allowing for easy, clinically relevant dosing\u003c\/li\u003e\n\n\u003cli\u003e Suitable for vegetarians and vegans\u003c\/li\u003e\n\n\n\u003c\/ul\u003e\n [TABS]\n\u003ch5\u003e Description\u003cbr\u003e\n\n\u003c\/h5\u003e\n\u003cp\u003e Palmitoylethanolamide (PEA) is an endogenously produced lipid that mediates the resolution of neuroinflammation and clinically reduces pain of various origins. PEA is a type of ethanolamine fatty acid produced in microglia and mast cells, where it reduces the activation of these two cell types; PEA levels are increased in brain areas involved in nociception and appear to modulate protective responses to both inflammation and pain. Its effects are mediated by direct activation of PPAR-a and GPR55 receptors, and potentially by indirect activation of CB1 and CB2 receptors and the TRPV1 channel (i.e. the capsaicin receptor).\u003cbr\u003e\u003cbr\u003e In clinical trials, PEA has been shown to be effective in reducing pain levels related to various chronic conditions (lasting at least 6 months) when pain was not controlled by standard therapies, by demonstrating its effectiveness both alone and in combination with standard treatments. PEA has been shown to be effective for pain resulting from nerve compression syndromes, including sciatica and carpal tunnel syndrome. Randomized trials have also shown benefit for pain control in specific conditions, including TMJ, as well as for depressive symptoms in major depressive disorder when used in conjunction with antidepressants. Furthermore, PEA has been shown to improve endothelial function and reduce intraocular pressure in patients with ocular hypertension.\u003c\/p\u003e\n\u003ch5\u003e Dosage\u003cbr\u003e\n\n\u003c\/h5\u003e\n\u003cp\u003e\u003cmeta charset=\"UTF-8\"\u003e \u003cb data-mce-fragment=\"1\"\u003eAdults:\u003c\/b\u003e \u003cspan data-mce-fragment=\"1\"\u003e1 capsule 1 to 3 times daily or as recommended by a healthcare practitioner.\u003c\/span\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003e Nutritional information\u003cbr\u003e\n\n\u003c\/h5\u003e\n\u003cp\u003e \u003cb\u003eMedicinal ingredients per capsule:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul\u003e\n\n\u003cli\u003e Palmitoylethanolamide (PEA) 400 mg\u003cbr\u003e PEA (palmitoylethanolamide) is a fatty acid-like compound extracted from non-GMO safflower oil. Micronized for better solubility and absorption.\u003c\/li\u003e\n\n\n\u003c\/ul\u003e\n\u003cp\u003e\u003cmeta charset=\"UTF-8\"\u003e \u003cspan\u003e\u003cb\u003eNonmedicinal ingredients:\u003c\/b\u003e Vegetable capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), silica, stearic acid.\u003c\/span\u003e\u003c\/p\u003e"}