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Chronic venous insufficiency leads to symptoms of itching, pain, discoloration and edema in the legs, creating both medical and aesthetic concerns. Modern research has confirmed that the active ingredient responsible for improving blood vessel integrity is known as escin. Escin has been found to increase nitric oxide production within the endothelial cells, thereby improving blood flow.\u003c\/p\u003e\n\u003cp\u003eClinical trials have found that horse chestnut extract can reduce pain and leg swelling associated with chronic venous insufficiency and also significant reduction in symptoms, bleeding, and improvements in endoscopic evaluations in those with hemorrhoids. One trial showed that 82% of subjects had hemorrhoid improvements compared to only 32% in placebo, with most benefits acutely apparent within just six days of starting supplementation. Conversely, many studies for chronic venous insufficiency find that maximum benefits occur within 1-3 months of supplementation. 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Chronic venous insufficiency leads to symptoms of itching, pain, discoloration and edema in the legs, creating both medical and aesthetic concerns. Modern research has confirmed that the active ingredient responsible for improving blood vessel integrity is known as escin. Escin has been found to increase nitric oxide production within the endothelial cells, thereby improving blood flow.\u003c\/p\u003e\n\u003cp\u003eClinical trials have found that horse chestnut extract can reduce pain and leg swelling associated with chronic venous insufficiency and also significant reduction in symptoms, bleeding, and improvements in endoscopic evaluations in those with hemorrhoids. One trial showed that 82% of subjects had hemorrhoid improvements compared to only 32% in placebo, with most benefits acutely apparent within just six days of starting supplementation. Conversely, many studies for chronic venous insufficiency find that maximum benefits occur within 1-3 months of supplementation. The evidence-based dose for\u0026nbsp;\u003cem\u003eAesculus hippocastanum\u0026nbsp;\u003c\/em\u003eappears to be mostly dependent on escin content, which should reach a minimum 150 mg per day, rather than the dried herb equivalent or total extract amount.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHorse Chestnut\u0026nbsp;\u003c\/strong\u003efrom Cyto- Matrix contains 375mg of\u0026nbsp;\u003cem\u003eAesculus hippocastanum\u0026nbsp;\u003c\/em\u003eseed extract, standardized to contain a minimum of 20% escin content (75mg) per vegetable capsule.\u0026nbsp;\u003cstrong\u003eHorse Chestnut\u003c\/strong\u003e\u0026nbsp;is also guaranteed to be free of esculin, a coumarin compound that can cause gastric distress in significant amounts. Each bottle of\u0026nbsp;\u003cstrong\u003eHorse Chestnut\u0026nbsp;\u003c\/strong\u003econtains 90 vegetable capsules.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHorse Chestnut\u0026nbsp;\u003c\/strong\u003eis a part of the Cyto-Matrix Herbal Matrix Series, containing sustainably sourced, traceable and GMO free herbs with potent therapeutic properties. Each herb is extracted and tested to ensure the standardization of active ingredients, ultimately leading to efficacious, predictable and reliable products. The Cyto-Matrix Herbal Matrix Series of herbal extracts is beneficial for both the health of individuals, and also the health of our planet and future generations.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003c\/em\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eDosage\u003cbr\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003e\u003cb\u003eAdults:\u003c\/b\u003e Take 1 capsule, 1-2 times daily, or as recommended by a healthcare practitioner.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003eNutrition info\u003cbr\u003e\u003c\/h5\u003e\n\u003cp\u003e\u003cstrong\u003eIngredient (per capsule):\u003c\/strong\u003e\u003cbr\u003eHorse-chestnut extract (seed, Aesculus hippocastanum) Aescin 20%, 5:1, DHE 1875mg 375mg\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cb\u003eNon-medicinal ingredients:\u003c\/b\u003e Vegetable grade magnesium stearate, microcrystalline cellulose, brown rice flour. Capsule: hypromellose.\u003c\/span\u003e\u003c\/p\u003e\n[\/TABS]"}

Horse Chestnut

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Horse Chestnut

Vendor: Cyto-Matrix
NPN: 80108723

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  • 375 mg (5:1 extract; dried herb equivalent [DHE] 1875 mg) Aesculus hippocastanum seed extract, standardized to contain a minimum of 20% escin (75 mg) per vegetable capsule
  • Designed to improve blood flow, capillary integrity and venous insufficiency conditions such as hemorrhoids and varicose veins
  • Guaranteed free of esculin, a coumarin compound that can cause stomach upset in significant amounts

Aesculus hippocastanum, also known as Horse Chestnut, is a herb traditionally used to improve symptoms of chronic venous insufficiency such as hemorrhoids and varicose veins. Chronic venous insufficiency leads to symptoms of itching, pain, discoloration and edema in the legs, creating both medical and aesthetic concerns. Modern research has confirmed that the active ingredient responsible for improving blood vessel integrity is known as escin. Escin has been found to increase nitric oxide production within the endothelial cells, thereby improving blood flow.

Clinical trials have found that horse chestnut extract can reduce pain and leg swelling associated with chronic venous insufficiency and also significant reduction in symptoms, bleeding, and improvements in endoscopic evaluations in those with hemorrhoids. One trial showed that 82% of subjects had hemorrhoid improvements compared to only 32% in placebo, with most benefits acutely apparent within just six days of starting supplementation. Conversely, many studies for chronic venous insufficiency find that maximum benefits occur within 1-3 months of supplementation. The evidence-based dose for Aesculus hippocastanum appears to be mostly dependent on escin content, which should reach a minimum 150 mg per day, rather than the dried herb equivalent or total extract amount.

Horse Chestnut from Cyto- Matrix contains 375mg of Aesculus hippocastanum seed extract, standardized to contain a minimum of 20% escin content (75mg) per vegetable capsule. Horse Chestnut is also guaranteed to be free of esculin, a coumarin compound that can cause gastric distress in significant amounts. Each bottle of Horse Chestnut contains 90 vegetable capsules.

Horse Chestnut is a part of the Cyto-Matrix Herbal Matrix Series, containing sustainably sourced, traceable and GMO free herbs with potent therapeutic properties. Each herb is extracted and tested to ensure the standardization of active ingredients, ultimately leading to efficacious, predictable and reliable products. The Cyto-Matrix Herbal Matrix Series of herbal extracts is beneficial for both the health of individuals, and also the health of our planet and future generations.


Adults: Take 1 capsule, 1-2 times daily, or as recommended by a healthcare practitioner.

Ingredient (per capsule):
Horse-chestnut extract (seed, Aesculus hippocastanum) Aescin 20%, 5:1, DHE 1875mg 375mg

Non-medicinal ingredients: Vegetable grade magnesium stearate, microcrystalline cellulose, brown rice flour. Capsule: hypromellose.

You have questions ?

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You can reach our team of experts by telephone Monday to Friday from 10 a.m. to 5 p.m. We will be able to help you choose the right product for you.

+1 877-575-0616
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Horse Chestnut

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